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BMG LabTech CLARIOstar Plus Multi-Mode Plate Reader

Are you looking for a high-performance microplate reader? Look no further than Clariostar Plus. With cutting-edge technology and user-friendly features, this instrument is the perfect choice for any lab.

Original price was: $37,999.00.Current price is: $19,999.00.

SKU:CLARIOstar Plus

CLARIOstar Plus is a modularly expandable high-performance microplate reader that meets all laboratories’ current and future requirements. The device measures the leading detection technologies, including UV/vis absorbance, fluorescence intensity (incl. FRET), luminescence (incl. BRET), fluorescence polarization, time-resolved fluorescence (incl. TR-FRET), and AlphaScreen.

“I am using the clariostar plus plate reader for luminescence-, fluorescence-, FRET- and BRET-based assays. The plate readers shows a very good performance in all these modes and the user-friendly, intuitive control surface facilitates the fast setup of new experiments. The analysis software MARS enables a fast analysis and export of the raw data. What would improve the performance of the plate reader in dual-color assays (FRET & BRET), is the design of a filter cube that would allow for the simultaneous detection of both channels (as feasible with, e.g., the Neo2 plate from BioTek).”

CLARIOstar® multimodal reader, unlike readers equipped with classic monochromators, allows you to change the transmission slit width from 8 to 100 nm, significantly increasing its sensitivity. The presence of a library of fluorophores built into the software greatly simplifies the workflow.

 

Features

Advantages

  • It’s all on board: monochromator, filters, and spectrometer for maximum flexibility and sensitivity.
  • Simplified measurement setup: widest concentration and signal intensity range, auto-focus function
  • Optimized for long-term measurements with living cells: easy control of O2, CO2, de-, and re-oxygenation

Compared to its predecessor, the CLARIOstar Plus features Enhanced Dynamic Range and Auto Focus technology, which aim to eliminate the need for manual adjustment and make detection optimization easier than before. Specialized detectors (PMTs) for different measurement methods offer additional flexibility.

The CLARIOstar Plus combines the sensitivity of filters and the flexibility of monochromators in a revolutionary new technology: our patented LVF Monochromator.

Three technologies guarantee reliable results with every measuring method:

  • LVF monochromators combine flexibility and sensitivity for fluorescence intensity and luminescence measurements
  • Filters ensure excellent sensitivity for all measurement methods (excluding absorption)
  • The spectrometer records entire absorption spectra in a very short time

The ClarioStar Plus can perform modern cell/molecular/high throughput assays, including:

  • DNA,RNA and Protein quantification
  • Cell based assay / Long Term Kinetic Live Cell Assays
  • Enzyme and Kinetic assays
  • Genotyping  & Reporter gene assays
  • Molecular binding assays
  • ELSIA
  • Fluorescence Polarization
  • Bioluminescent Resonance Energy Transfer (BRET)
  • Time Resolved Fluorescence (TRF)

Sample Input:

  • Sample preparations in 6-384 well plates
  • The CLARIOstar Plus is equipped with Dual Reagent Dispensers (Dead volume 600ml)

Light Sources:

  • High energy xenon flash lamp
  • Dedicated Laser for Alphascreen / AlphaLISA / Alphaplex

Detection Modes:

  • UV/Vis absorbance
  • Fluorescence intensity
  • Luminescence
  • Fluorescence polarization
  • Time-resolved fluorescence
  • TR-FRET
  • Alphascreen / AlphaLISA / Alphaplex

Measurement Modes:

  • Top and bottom reading
  • Endpoint and Kinetic
  • Sequential multi-excitation
  • Sequential multi-emission
  • Spectral scanning (Absorbance, Luminescence, Fluorescence)
  • Ratiometric measurements
  • Well scanning

More time for your research – simple, automated, and flexible handling

The modularly expandable CLARIOstar Plus covers all the main detection technologies and is suitable even for highly demanding laboratory routines.

The monochromator lets you adjust the wavelengths and bandwidths for fluorescence and luminescence measurements quickly and easily.

Additional filters and an ultrafast UV/vis spectrometer for absorption measurements give you flexibility and speed.

The “Enhanced Dynamic Range” (EDR) feature simplifies the measurement setup and saves time.

Simply start your measurement, and the device will determine the ideal settings automatically. A single measurement covers the widest possible range of concentrations or signal intensities (8 orders of magnitude).

Perform long series of measurements with living cells feeling relaxed: thanks to the robust shaking and temperature control function, you can incubate your cells directly in the instrument. An atmospheric control unit (ACU) ensures the optimal composition of gases for each cell type. The ACU also allows de- and re-oxygenation, thus suitable for in vitro models of diseases such as ischemia/reperfusion.

Specification

Wavelength Range:
240 to 740 nm or 240 – 900 (red shifted PMT) for FI, FP, FRET, TRF, TR-FRET (filters),
240 to 740 nm for LUM (filters),
320 to 740 nm or 320 – 840 nm (red shifted PMT) for FI, FRET, TRF (monochromators),
240 to 740 nm for LUM (filters),
320 to 740 nm for LUM (monochromator),
220 to 1000 nm for ABS.
Optical System:
High energy xenon flash lamp,
Dedicated Laser for AlphaScreen® / AlphaLISA®,
Filters: Excitation and emission slides for 4 filters each,
LVF Monochromator™ : Excitation and Emission.
Detector(s): Low noise photomultiplier tube CCD spectrometer.
Light Source: High energy xenon flash lamp.
Measuring Time: Reading Times (Flying Mode): 9 seconds (96 wells), 14 seconds (384 wells), 27 seconds (1536 wells).
Plate Formats: 6 to 1536-well plates, LVis Plate with sixteen 2 µL microspots.
Detection System: DetectionFluorescence Intensity – including FRET, Fluorescence Polarization / Anisotropy, AlphaScreen® / AlphaLISA®, Luminescence (flash and glow) – including BRET, Time-Resolved Fluorescence – including TR-FRET, UV/Vis Absorbance Spectra

Include:

  • Installation and training BMG Labtech for CLARIOstar include installation and 1-day training for up to 4 users.
  • Bar code reader BMG Labtech for stacker III
  • Calibration BMG Labtech of EVPlate (681-101) with certification (recommended every two years)
  • EV Performance test plate BMG Labtech multimode validation plate. As listed under CLARIOstar
  • H3 Spoon BMG Labtech

Reference Library

CLARIOstar® Microplate Reader Specifications

Detection ModesFluorescence Intensity FRET Fluorescence Polarization AlphaScreen®/AlphaLISA®/AlphaPlexTM Luminescence(flash and glow) BRET Time-Resolved Fluorescence - including TR-FRET UV/Vis absorbance spectra
Measurement ModesTop and bottom reading Endpoint and kinetic measurements Sequential multi-excitation measurements Sequential multi-emission measurements Spectral scanning (fluorescence, luminescence, absorbance) Ratiometric measurements Well scanning
Microplate Formats6- to 1536-well plates, user-definable LVis Plate with 16 low volume microspots (2 μL)
Microplate CarrierRobot compatible
Light SourcesHigh energy xenon flash lamp Dedicated laser for AlphaScreen®/AlphaLISA®/AlphaPlexTM
DetectorsLow noise photomultiplier tube CCD spectrometer
Wavelength SelectiondualDual Linear Variable Filter (LVF) Monochromators™Linear Variable Dichroic Mirror Separates Ex & Em LVF Monochromators Optical filters: Ex and Em slides hold 4 filters each LVF Monochromators + optical filters Use one for Ex and the other for Em UV/Vis absorbance spectrometer: Full spectra or 8 distinct wavelengths in < 1 sec/well
Optical FiltersExcitation and emission slides for 4 filters each
Optical Path GuidesTop and bottom: Enclosed, free-air optical light path guided by motor-driven mirrors and dichroics
Z-AdjustmentAutomatic focal height adjustment (0.1 mm resolution)
Spectral RangeFilters240 - 750 nm or 240 - 900 nm for FI, FP, TRF 240 - 750 nm for LUM
LVF Monochromators™320 - 850 nm for FI 320 - 750 nm for LUM
Linear Variable Dichroic340 - 740 nm for FI, LUM
Spectrometer220 - 1000 nm for ABS
Sensitivity*FI Filters (top)< 0.15 pM (< 3 amol/well Fluorescein, 384sv, 20 μL)
FI Filters (bottom)< 1.0 pM (< 50 amol/well Fluorescein, 384g, 50 μL)
FI Monochromator (top)< 0.35 pM (< 7 amol/well Fluorescein, 384sv, 20 μL)
FI Monochromator (bottom)< 3.0 pM (< 150 amol/well Fluorescein, 384g, 50 μL)
FP< 0.5 mP SD at 1 nM Fluorescein (384sv, 20 μL)
HTRF® (black and white microplates)Reader Control Kit (Eu) after 18h (384sv, 20 μL) Delta F > 880 % (High Calibrator) Delta F > 30 % (Low Calibrator)
TRF< 20 fM Europium, 384, 80 μL
LUM< 0.4 pM (< 8 amol/well ATP, 384sv, 20 μL) Dynamic Range: 9 decades
AlphaScreen® with Laser< 5 pM (< 100 amol/well P-Tyr-100, 384sv, 20 μL)
ABS with SpectrometerFull spectrum captured in < 1 s / well Selectable spectral resolution: 1, 2, 5, and 10 nm OD range: 0 - 4 OD Accuracy: < 1% at 2 OD Precision: < 0.5% at 1 OD and < 0.8% at 2 OD
Read TimesFlying mode (1 flash)8 s (96), 15 s (384), 28 s (1536)
10 flashes19 s (96), 57 s (384), 3 min 4 s (1536)
Reagent InjectionUp to 2 built-in reagent injectors Individual injection volumes for each well: 3 to 500 µL (optionally up to 2 mL) Variable injection speed up to 420 µL / s Reagent back flushing
ShakingLinear, orbital, and double-orbital with user-definable time and speed
Incubation+3 °C above ambient up to 45 °C or 65 °CThe upper heating plate of the incubation chamber operates at 0.5 °C more than the lower plate. This prevents condensation build-up on the lid or sealer.
SoftwareIntegrated fluorophore library Multi-user Reader Control and MARS Data Analysis Software included FDA 21 CFR Part 11 compliant
DimensionsWidth: 45 cm, depth: 51 cm, height: 40 cm; weight: 32 kg

Optional Accessories

LVis PlateSample Capacity: Sixteen separate microdrop wells for 2 µL samples; One standard cuvette position for up to 1 mL samples.Quality Control Internal Standards (optional): Four NIST traceable optical density filters (approximate values of 0.1, 0.3, 0.6 and 1.0 OD); One holmium oxide filter for wavelength accuracyDimensions: Conforms to SBS standards for microplates.
Atmospheric Control Unit (ACU)Actively regulates O2 and CO2 - 0.1-20%
StackerMagazines for up to 50 plates - continuous loading feature
THERMOstarMicroplate Incubator and Shaker
Optical FiltersExcitation and emission slides for 4 filters each
UpgradesPlease contact your local DSS representative for upgrades including options such as detection modes, reagent injectors, etc.
*LOD = 3 x SD (20 blanks) / slope (6 pt std curve) AlphaScreen® P-Tyr-100 assay kit, PerkinElmer, #6760620C Microplates:
  • White for LUM, AlphaScreen®, TRF
  • Black for FI, FP
  • Clear for ABS
96 = 96-well microplates 384sv = 384-well small volume microplates 384g = 384-well glass bottom microplates 1536 = 1536-well microplates

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